Positions

Postdoc proteomics method development

We have a post-doctoral position available at Utrecht University in the Biomolecular Mass Spectrometry and Proteomics group. The research in the group emphasizes on the development of advanced mass spectrometry-based proteomics methods to address questions in relevant biological systems. The laboratory houses an excellent infrastructure, including a dozen state-of-the-art mass spectrometers, advanced separation technologies, bioinformatics, and laboratories for cell culture, biochemistry and molecular biology. The research group is vibrant and houses over 15 nationalities – Utrecht is a great place to be!

For this position, the work is embedded in the Netherlands X-omics Initiative (https://www.x-omics.nl/) and participation in local meetings, the proteomics pillar and helpdesk for this consortium is expected. The aim is to integrate developed technologies and data analysis into multi-omics workflows.

Position: Post-doc proteomics method development in an X-omics environment

In recent years we have developed new proteomics methods ranging from improved separation and enrichment methodologies to new fragmentation techniques and targeted analysis of post-translation modifications (PTMs). These improvements enable us to decipher the complexity of the human proteome, consisting of dynamic protein-protein interactions, PTMs, protein synthesis and degradation, protein complex assembly and disassembly, etc. To further advance the impact of our proteomics tools in the biological and clinical setting, smooth integration with other omics technologies such as genomics and metabolomics is a prerequisite.

For this position, we seek a highly motivated biochemist or analytical chemist with proven expertise in mass spectrometry and proteomics. Having your own project, you will team-up with dedicated researchers combining expertise in biochemistry, analytical chemistry, mass spectrometry and bioinformatics to further develop state-of-the-art proteomics methods that will answer pressing biological questions. As part of the Netherlands X-omics Initiative you will interact and collaborate with national and international researchers to enable the efficient integration of proteomics data and workflows with other omics technologies and enable the translation of the integrated X-omics datasets into biologically relevant information.

Recent illustrative work

  1. Kleinpenning F, et al. (2020) Fishing for newly synthesized proteins with phosphonate-handles. Nature Communications 11(1), 3244.
  2. Schmidlin T, et al. (2019) High-Throughput Assessment of Kinome-wide Activation States. Cell Systems 9(4):366-374.
  3. Ressa A, et al.  (2018) A System-wide Approach to Monitor Responses to Synergistic BRAF and EGFR Inhibition in Colorectal Cancer Cells. Molecular & Cellular Proteomics. 17(10), 1892-1908.

Information

  1. Position: PostDoc
  2. Location: Utrecht University, Utrecht, Netherlands
  3. Duration: 4 years (PostDoc)
  4. Start date: After consultation, as soon as possible
  5. Background: Experience with Proteomics Workflows, systems biology, high end proteomics is appreciated
  6. Apply with motivation letter, CV and 2 references
  7. Deadline for application: 15th of November 2020
  8. For further information contact m.altelaar@uu.nl, applications can be send to: c.c.heuzer@uu.nl

Technician Analytical Biomolecular Mass Spectrometry

As our new technician you will assist in the general research projects, with emphasis on proteomics workflows consisting of sample preparation, chromatographic separation, and MS-based characterization and quantitation of peptides and proteins. In addition, you will support the group by measuring intact native proteins with specialized mass spectrometry instrumentation, like HDX, Orbi-traps and TOF’s.

Part of your time will go into managing and running a fee for service to biopharmaceutical companies, by solving ‘research’ questions using native mass spectrometry.

You will support the proteomics research by maintaining analytical equipment such as the HPLC (RP, SEC, IEX, HpH), centrifuges, etc. Furthermore, you will maintain the stock of consumables and materials and where needed assist in testing and improving the used methodology and instrumental setup.

Qualifications

  • We are looking for a hands-on, flexible, self-motivated colleague who is also a team player, open minded and creative and last but not least: you are driven by knowledge and results through your passion and enthusiasm
  • a bachelor’s or master’s in science education in analytical chemistry, biochemistry or related field;
  • good interpersonal skills and a proven ability to communicate effectively and work well with your colleagues;
  • self-initiative and you are eager to learn and to improve current workflows;
  • the ability to follow instructions and take direction;
  • Skills in using standard productivity software;
  • demonstrated knowledge and experience in mass spectrometric techniques like LC-MS/MS, proteomics and native mass spectrometry (considered a plus);
  • experience with analytical and biochemical methods such as liquid chromatography based fractionation of peptides and proteins (considered a plus);
  • good verbal and written communication skills in Dutch and/or English and can maintain/build good customer relations.

Information:
Position: technician
Location: Utrecht University, Utrecht, Netherlands
Duration: 1 year with the option of extension
Start date: after consultation; as soon as possible

Apply with motivation letter, cv and 2 references

Deadline for application: December 1, 2020

For information or application: Corine Heuzer, c.c.heuzer@uu.nl